AMPK, metabolism, and vascular function

Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor activated during stress that plays key role in maintaining homeostasis. This ubiquitous signaling pathway has been implicated multiple functions including mitochondrial biogenesis, redox regulation, cell growth and proliferation, autophagy inflammation. The protective of AMPK cardiovascular function the involvement dysfunctional pathogenesis disease have highlighted recent years. In this review, we summarize discuss regulation blood flow response to metabolic demand basis physiological anticontractile, antioxidant, anti-inflammatory, antiatherogenic actions vascular system. Investigations by others us demonstrated endothelial function, homeostasis, inflammation, addition its hypoxia ischemia/reperfusion injury. pathophysiological implications with regard complications therapeutic potential activators are also discussed.